Absolute bioavailability, tissue distribution, and excretion of 2, 4, 5-trimethoxybenzaldehyde in rats. (August 2017)

• Record Type: Journal Article
• Authors: Wu, Yi-Kai; Chen, Chin-Chu; Lin, Ting-Wei; Tsai, Pei-Ching; Kuo, Chia-Feng
• Is Part Of: Journal of functional foods. Volume 35(2017)
• Page Start: 90
• Page End: 96
• Publication Date: 2017-08
• Subjects: 2, 4, 5-Trimethoxybenzaldehyde -- Bioavailability -- Pharmacokinetics; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2017.05.035
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: 2, 4, 5-TMBA absorption starts before it reaches the intestines. The absolute bioavailability of 2, 4, 5-TMBA in rat was estimated as 62.77%. Total amount of unconverted 2, 4, 5-TMBA eliminated in feces and urine in 24 h is only 0.03% of oral dosage administrated. Abstract: 2, 4, 5-Trimethoxybenzaldehyde (2, 4, 5-TMBA), a natural inhibitor of cyclooxygenase II activity, is a bitter principle present in plants. In our previous study, 2, 4, 5-TMBA suppresses differentiation of preadipocytes and enhances lipolysis in mature adipocytes. This study aimed to investigate the absolute bioavailability, tissue distribution, and excretion of 2, 4, 5-TMBA in Sprague-Dawley rats. After oral administration (po) and intravenous administration (iv) of 100 and 10 mg/kg 2, 4, 5-TMBA, respectively, the absolute bioavailability was estimated as 62.77% by calculating [(AUCpo × Doseiv )/(AUCiv × Dosepo )] × 100% (AUC: area under curve). Half hour after oral administration, 2, 4, 5-TMBA reached the highest concentration of 211.661 μg/g in stomach. In one hour, 2, 4, 5-TMBA reached the highest concentrations in heart, liver, kidney, small intestine, and large intestine. Total amount of unconverted 2, 4, 5-TMBA eliminated in feces and urine in 24 h is only 0.03% of oral dosage administrated. The data presented provides useful information for the future application of 2, 4, 5-TMBA as nutraceutical.