New sesquiterpenoids from Petasites japonicus and Petasites tricholobus. (February 2018)

• Record Type: Journal Article
• Authors: Hai, Ping; Gao, Yuan; Xiao, Chun-Gui; Jiang, Xian-Jun; Li, Xiang-Mei; Yang, Wan-Qiu; Li, Rong-Tao; Wang, Fei
• Is Part Of: Phytochemistry letters. Volume 23(2018)
• Page Start: 41
• Page End: 45
• Publication Date: 2018-02
• Subjects: Compositae -- Petasites japonicus -- Petasites tricholobus -- 15-noreremophilane -- Bakkenolide -- Sesquiterpenoid; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2017.10.008
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Six new sesquiterpenoids were isolated from Petasites japonicus and Petasites tricholobus . The structures of new compounds were elucidated by NMR and HRESIMS analyses. The new compound6 represented the first example of 15-noreremophilane sesquiterpenoid from the genus Petasites . Abstract: Phytochemical investigation of the whole plants of Petasites japonicus and Petasites tricholobus led to the isolation of five new bakkenolide-type sesquiterpenoids, bakkenolide-Ib (1 ), bakkenolide-IIb (2 ), bakkenolide-IIIb (3 ), bakkenolide-IVb (4 ), and bakkenolide-Vb (5 ), and a new eremophilane-type norsesquiterpenoid, petasindiol (6 ). Their structures were elucidated by NMR and HRESIMS analyses. Petasindiol (6 ) represented the first example of 15-noreremophilane sesquiterpenoid from the genus Petasites .