Effects of a lupin protein concentrate on lipids, blood pressure and insulin resistance in moderately dyslipidaemic patients: A randomised controlled trial. (October 2017)

• Record Type: Journal Article
• Authors: Pavanello, Chiara; Lammi, Carmen; Ruscica, Massimiliano; Bosisio, Raffaella; Mombelli, Giuliana; Zanoni, Chiara; Calabresi, Laura; Sirtori, Cesare R.; Magni, Paolo; Arnoldi, Anna
• Is Part Of: Journal of functional foods. Volume 37(2017)
• Page Start: 8
• Page End: 15
• Publication Date: 2017-10
• Subjects: Lupin protein -- Lipids -- PCSK9 -- Blood pressure -- Glycaemic control; ACE angiotensin converting enzyme -- ApoA-I apolipoprotein A-I -- ApoB apolipoprotein B -- BMI body mass index -- BP blood pressure -- CK creatine kinase -- CRP C-reactive protein -- CV cardiovascular -- DBP diastolic blood pressure -- EGF-A first epidermal growth factor-like repeat -- ELISA enzyme-linked immunosorbent assay -- F females -- FG fasting glucose -- HDL-C high-density lipoprotein cholesterol -- HC hip circumference -- HOMA-IR homeostasis model assessment for insulin resistance -- LDL-C low-density lipoprotein cholesterol -- Lp(a) lipoprotein(a) -- M males -- NCEP National Cholesterol Education Program -- PCSK9 proprotein convertase subtilisin/kexin type 9 -- SBP systolic blood pressure -- SD standard deviation -- sICAM-1 soluble intercellular adhesion molecule-1 -- TG triglycerides -- WC waist circumference; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2017.07.039
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: A lupin concentrate and a skimmed milk powder tested on lipids and cardiovascular risk factors. Randomised, parallel, double-blind, single-centre study, 12-week intervention. Reductions of LDL-C, non-HDL-C, and PCSK9 significant only after the lupin diet. Significant reduction of HDL-C concentration only observed after the milk diet. Abstract: The study had the objective of evaluating the effects of a lupin protein concentrate on plasma lipids and other cardiovascular risk factors, e.g. blood pressure and insulin resistance, compared to a skimmed milk powder. Fifty subjects followed a randomised, parallel, double-blind, single-centre study, consisting in a 12-week intervention: half of the participants consumed a lupin protein concentrate (30 g/day of protein), the other half a lactose-free skimmed milk powder (30 g/day of protein), both integrated into a mixed low-lipid diet. At the end of intervention, both groups showed similar reductions of total cholesterol concentrations versus baseline (−6.7%, and −7.2%, respectively), but the reductions of LDL-cholesterol (−8.0%), non-HDL-cholesterol (−7.5%), and proprotein convertase subtilisin/kexin type 9 (PCSK9) (−12.7%) levels were statistically significant only after the lupin diet. A significant reduction of HDL-cholesterol concentration was observed only after the milk diet. The differences between the two groups, however, were not statistically significant.