Polysaccharide peptides from Coriolus versicolor: A multi-targeted approach for the protection or prevention of alcoholic liver disease. (January 2018)

• Record Type: Journal Article
• Authors: Ren, Yilin; Geng, Yan; Chen, Hedi; Lu, Zhen-Ming; Shi, Jin-Song; Xu, Zhenghong
• Is Part Of: Journal of functional foods. Volume 40(2018)
• Page Start: 769
• Page End: 777
• Publication Date: 2018-01
• Subjects: Polysaccharide peptides from Coriolus versicolor -- Alcoholic liver disease -- Steatosis -- AMPK -- Inflammation; ALD alcoholic liver disease -- ACC acetyl-CoA carboxylase -- ALT alanine transaminase -- AST aspartate transaminase -- AMPK AMP-activated protein kinase -- CD14 cluster of differentiation 14 -- ChREBP Carbohydrate-responsive element-binding protein -- CPT-1 carnitine palmitoyltransferase I -- CYP2E1 cytochrome P450 2E1 -- FAS fatty acid synthase -- GAPDH glyceraldehyde-3-phosphate dehydrogenase -- HDL high-density lipoprotein -- H&E hematoxylin and eosin -- HO-1 heme oxygenase 1 -- IL-1β interleukin-1 beta -- IL-6 interleukin-6 -- LDL low-density lipoprotein -- Ldlr low density lipoprotein receptor -- LPS Endotoxin -- MAPK mitogen-activated protein kinase -- MDA microscale malondialdehyde -- MyD88 myeloid differentiation primary response 88 -- NEFA nonesterified Free fatty acids -- NF-κB nuclear transcription factor- kappa B -- NF-κB p65 nuclear transcription factor-kappa B p65 -- CMC-Na sodium carboxymethyl cellulose -- p-ACC phospho-acetyl-CoA carboxylase -- p-AMPKα phospho-AMP-activated kinase alpha -- PPARα peroxisome proliferator–activated receptor α -- PPARγ peroxisome proliferator–activated receptor γ -- ROS reactive oxygen species -- SCFA Short-chain fatty acids -- SREBP1c sterol regulatory element-binding protein 1c -- TC total cholesterol -- TG triacylglycerol -- TLR-2 Toll-like receptor 2 -- TLR-4 Toll-like receptor 4 -- TNF-α tumor necrosis factor α; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2017.11.051
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Investigated the preventive effect of PSP on alcohol-induced liver injury in mice. PSP alleviates alcoholic fatty liver via the AMPK pathway. PSP regulates ethanol-induced endotoxin-mediated inflammation. PSP has potential as a dietary supplement or prescription for ALD. Abstract: Alcoholic liver disease (ALD) is a major cause of liver-related morbidity and mortality worldwide. In this paper, we investigated the preventive effect of polysaccharide peptide (PSP), isolated from JNPF-CV05 strain of Coriolus versicolor, on alcohol-induced liver injury in mice. Our data demonstrated that PSP supplementation attenuated ethanol-induced aspartate transaminase (ALT), aspartate transaminase (AST), and microscale malondialdehyde (MDA). Pre-treatment with PSP also significantly decreased ethanol-induced plasma levels of total cholesterol (TC), triacylglycerol (TG), and endotoxin concentration. Mechanistically, PSP treatment upregulated ethanol stimulated the hepatic expression of AMP-activated protein kinase (AMPK), acetyl-CoA carboxylase (ACC) and peroxisome proliferator–activated receptor α (PPARα) to inhibit hepatic lipid accumulation. In addition, PSP markedly reduced ethanol stimulated inflammation via inhibiting Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) mediated nuclear transcription factor- kappa B (NF-κB) signaling pathway. In conclusion, PSP is effective in ameliorating ethanol-induced hepatic steatosis and injury through reducing lipid accumulation during the development of fatty liver and alleviating endotoxin-mediated inflammation. Our findings strengthen that PSP has potential as a dietary supplement or prescription for ALD.