Chemical constituents from leaves and root bark of Trichilia monadelpha (Meliaceae). (February 2018)

• Record Type: Journal Article
• Authors: Nangmo, Kemda Pamela; Tsamo, Tontsa Armelle; Zhen, Liu; Mkounga, Pierre; Akone, Sergi Herve; Tsabang, Nole; Müller, Werner E.G.; Marat, Kirt; Proksch, Peter; Nkengfack, Augustin Ephrem
• Is Part Of: Phytochemistry letters. Volume 23(2018)
• Page Start: 120
• Page End: 126
• Publication Date: 2018-02
• Subjects: Trichilia monadelpha -- Monadelphin -- Trichin -- Cytotoxic activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2017.11.020
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Two new limonoids, monadelphin A and B (1-2), and two new sesquiterpenes, trichins A and B (3-4) were isolated. Compounds 1–4 were evaluated for cytotoxic potential. Compound 1 exhibits strong cytotoxicity against the mouse lymphoma L5178Y cell line with an IC50 value of 0.62 μg/mL. All compounds do not exhibit cytotoxic activities. Abstract: Two new limonoid derivatives designated, monadelphin A (1 ) and monadelphin B (2 ) and two new sesquiterpene derivatives named trichins A (3 ) and B (4 ) were isolated together with six known compounds (5 –10 ) from the mixture of methylene chloride/methanol (1:1) extract of leaves and root bark of Trichilia monadelpha (Meliaceae) collected in Cameroon. The structures of the new compounds were unambiguously established by detailed spectroscopic analysis including 1D and 2D NMR data in conjunction with high resolution mass spectrometry data and by comparison of these data with those of related compounds described in the literature. Compounds1–4 were screened for their cytotoxic potential. Compound1 showed strong cytotoxicity against the mouse lymphoma L5178Y cell line with an IC50 value of 0.62 μg/mL. The biogenetic origin of trichin B (4 ) from trichin A (3 ) was also postulated.