Amisulpride Augmentation for Clozapine-Refractory Positive Symptoms: Additional Benefit in Reducing Hypersialorrhea. (9th March 2015)

• Record Type: Journal Article
• Authors: Bogorni, Fabiani; Moreira, Frederico Fernandes; Pimentel, Eduardo Mylius; Grohs, Géder Evandro Motta; Diaz, Alexandre Paim
• Other Names: Inada Toshiya Academic Editor.
• Is Part Of: Case reports in psychiatry. Volume 2015(2015)
• Publication Date: 2015-03-09
• Subjects: Psychiatry -- Periodicals; Psychiatry -- Case studies -- Periodicals; Mental Disorders; Psychiatry; Psychiatry; Periodicals; Case studies; Periodicals; 616.89
• DOI: 10.1155/2015/408179
• Languages: English
• ISSNs: 2090-682X

Abstract

Abstract : One-third to half of patients taking clozapine suffer from refractory symptoms despite adequate treatment. Among other adverse effects, clozapine-induced hypersalivation (CIH) occurs in approximately half of all patients. This is a case of a 30-year-old male with refractory schizophrenia; in this patient, the remission of residual positive symptoms, as well as the reduction of CIH, was achieved by treatment with clozapine augmented with amisulpride.