Transcription infidelity and genome integrity: the parallax view. Issue 5 (20th October 2018)

• Record Type: Journal Article
• Authors: Gordon, Alasdair J.E.; Sivaramakrishnan, Priya; Halliday, Jennifer A.; Herman, Christophe
• Is Part Of: Transcription. Volume 9:Issue 5(2018)
• Page Start: 315
• Page End: 320
• Publication Date: 2018-10-20
• Subjects: Transcription fidelity -- DNA break repair -- GreAB -- DksA -- RecBCD -- Epimutation -- Genomic integrity -- Backtracked RNA polymerase -- DNA resection -- Genetic noise; Genetic transcription -- Periodicals; 572.8
• DOI: 10.1080/21541264.2018.1491251
• Languages: English
• ISSNs: 2154-1264

Abstract

ABSTRACT: It was recently shown that removal of GreA, a transcription fidelity factor, enhances DNA break repair. This counterintuitive result, arising from unresolved backtracked RNA polymerase impeding DNA resection and thereby facilitating RecA-loading, leads to an interesting corollary: error-free full-length transcripts and broken chromosomes. Therefore, transcription fidelity may compromise genomic integrity.