Effect of pitavastatin and atorvastatin on regression of atherosclerosis assessed using intravascular ultrasound: a meta-analysis. Issue 6 (September 2018)

• Record Type: Journal Article
• Authors: Liu, Hui; Zhang, Mingjun; Li, Delong; Tian, Jingjing; Wang, Xuyang; Pan, Jinyu; Liu, Dian; Li, Xiaowei; An, Fengshuang
• Is Part Of: Coronary artery disease. Volume 29:Issue 6(2018:Sep.)
• Publication Date: 2018-09
• Subjects: atorvastatin -- glycated hemoglobin -- intravascular ultrasound -- lipids -- pitavastatin; Coronary heart disease -- Periodicals; Coronary Disease -- Indexes; Coronary Disease -- Periodicals; 616.123005
• DOI: 10.1097/MCA.0000000000000613
• Languages: English
• ISSNs: 0954-6928

Abstract

Abstract : Background: The aim of this study is to compare the efficacy and safety of pitavastatin and atorvastatin using data from randomized-controlled trial pooled together by means of a meta-analysis and decide which is better. Methods: PubMed, CENTRAL, Web of Knowledge, and ClinicalTrials.gov website were searched for randomized-controlled trials published until October 2016. Eligible studies comparing pitavastatin with atorvastatin head to head and reporting the outcome of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), glycated hemoglobin, and intravascular ultrasound evaluation were enrolled. Heterogeneity was assessed by using the I 2 statistic, and the extracted data were estimated by fixed-effects model. Results: Eleven trials including a total number of 1733 participants were identified. Compared with atorvastatin, changes in the mean differences of LDL-C and HDL-C were 2.51 [95% confidence interval (CI): 1.17–3.86; I 2 =48%; P =0.0003] and 2.17 (95% CI: 1.42–2.91; I 2 =40%; P <0.00001), respectively, for pitavastatin. The changes in the mean differences of glycated hemoglobin was −0.15 (95% CI: −1.44–1.15; I 2 =0%; P =0.83) for pitavastatin compared with atorvastatin. For plaque volume, lumen volume, and external elastic membrane, the changes are −0.93 (95% CI: −3.04–1.19; I 2 =50%; P =0.39), 0.17 (95% CI: −2.91–3.26; I 2 =0%; P =0.91), and −0.43 (95% CI: −1.96–1.11; I 2 =4%; P =0.58), respectively, for pitavastatin versus atorvastatin. Conclusion: In this study, pitavastatin seems to be less effective in reducing LDL-C and elevating HDL-C level compared with atorvastatin. Moreover, there is no significant difference in changes of glycated hemoglobin and intravascular ultrasound evaluation between pitavastatin and atorvastatin.