Gadoxetic Acid–Enhanced Hepatobiliary-Phase Magnetic Resonance Imaging for Delineation of Focal Nodular Hyperplasia: Superiority of High-Flip-Angle Imaging. Issue 5 (September 2018)

• Record Type: Journal Article
• Authors: Sheng, Ruofan; Palm, Viktoria; Mayer, Philipp; Mokry, Theresa; Berger, Anne Katrin; Weiss, Karl Heinz; Longerich, Thomas; Kauczor, Hans Ulrich; Weber, Tim Frederik
• Is Part Of: Journal of computer assisted tomography. Volume 42:Issue 5(2018)
• Publication Date: 2018-09
• Subjects: contrast media -- focal nodular hyperplasia -- gadoxetic acid -- magnetic resonance imaging; Tomography -- Periodicals; Tomography -- Periodicals; Tomography; Periodicals; 616.0757
• DOI: 10.1097/RCT.0000000000000777
• Languages: English
• ISSNs: 0363-8715

Abstract

Abstract : Objective: The aim of this study was to investigate whether hepatobiliary-phase (HBP) flip-angle (FA) increase to 25° improves conspicuity of focal nodular hyperplasia (FNH) and enables HBP delay reduction. Methods: This was a retrospective study of 23 patients with 46 FNHs. In each patient, HBP was performed with reduced-delay high FA (early/high), standard-delay high FA (late/high), and standard-delay standard FA (standard). Relative enhancement of liver and FNH periphery, FNH periphery–to–liver contrast ratio, and FNH periphery–to–central scar contrast ratio were compared between each HBP. Results: Early/high, late/high, and standard HBPs were performed after 13.00 ± 2.12, 19.12 ± 3.10, and 19.68 ± 3.22 minutes, respectively. Liver and FNH periphery relative enhancement, FNH periphery–to–liver contrast ratio, and FNH periphery–to–central scar contrast ratio were higher for early/high and late/high than for standard HBP ( P < 0.001 to P = 0.0048). Conclusions: Increasing FA to 25° improves delineation of FNHs in HBP. Combining FA increase with delay reduction is superior to standard HBP and is sufficient for FNH characterization.