Air Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe. Issue 5 (September 2018)
- Record Type:
- Journal Article
- Title:
- Air Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe. Issue 5 (September 2018)
- Main Title:
- Air Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe
- Authors:
- Forns, Joan
Sunyer, Jordi
Garcia-Esteban, Raquel
Porta, Daniela
Ghassabian, Akhgar
Giorgis-Allemand, Lise
Gong, Tong
Gehring, Ulrike
Sørensen, Mette
Standl, Marie
Sugiri, Dorothee
Almqvist, Catarina
Andiarena, Ainara
Badaloní, Chiara
Beelen, Rob
Berdel, Dietrich
Cesaroni, Giulia
Charles, Marie-Aline
Eriksen, Kirsten Thorup
Estarlich, Marisa
Fernandez, Mariana F.
Forhan, Anne
Jaddoe, Vincent W.V.
Korek, Michal
Lichtenstein, Paul
Lertxundi, Aitana
Lopez-Espinosa, Maria-Jose
Markevych, Iana
de Nazelle, Audrey
Raaschou-Nielsen, Ole
Nieuwenhuijsen, Mark
Pérez-Lobato, Rocío
Philippat, Claire
Slama, Rémy
Tiesler, Carla M.T.
Verhulst, Frank C.
von Berg, Andrea
Vrijkotte, Tanja
Nybo Andersen, Anne-Marie
Heude, Barbara
Krämer, Ursula
Heinrich, Joachim
Tiemeier, Henning
Forastiere, Francesco
Pershagen, Göran
Brunekreef, Bert
Guxens, Mònica
… (more) - Abstract:
- Abstract : Background: Exposure to air pollution during pregnancy may increase attention-deficit/hyperactivity disorder (ADHD) symptoms in children, but findings have been inconsistent. We aimed to study this association in a collaborative study of eight European population-based birth/child cohorts, including 29, 127 mother–child pairs. Methods: Air pollution concentrations (nitrogen dioxide [NO2 ] and particulate matter [PM]) were estimated at the birth address by land-use regression models based on monitoring campaigns performed between 2008 and 2011. We extrapolated concentrations back in time to exact pregnancy periods. Teachers or parents assessed ADHD symptoms at 3–10 years of age. We classified children as having ADHD symptoms within the borderline/clinical range and within the clinical range using validated cutoffs. We combined all adjusted area-specific effect estimates using random-effects meta-analysis and multiple imputations and applied inverse probability-weighting methods to correct for loss to follow-up. Results: We classified a total of 2, 801 children as having ADHD symptoms within the borderline/clinical range, and 1, 590 within the clinical range. Exposure to air pollution during pregnancy was not associated with a higher odds of ADHD symptoms within the borderline/clinical range (e.g., adjusted odds ratio [OR] for ADHD symptoms of 0.95, 95% confidence interval [CI] = 0.89, 1.01 per 10 µg/m 3 increase in NO2 and 0.98, 95% CI = 0.80, 1.19 per 5 µg/m 3Abstract : Background: Exposure to air pollution during pregnancy may increase attention-deficit/hyperactivity disorder (ADHD) symptoms in children, but findings have been inconsistent. We aimed to study this association in a collaborative study of eight European population-based birth/child cohorts, including 29, 127 mother–child pairs. Methods: Air pollution concentrations (nitrogen dioxide [NO2 ] and particulate matter [PM]) were estimated at the birth address by land-use regression models based on monitoring campaigns performed between 2008 and 2011. We extrapolated concentrations back in time to exact pregnancy periods. Teachers or parents assessed ADHD symptoms at 3–10 years of age. We classified children as having ADHD symptoms within the borderline/clinical range and within the clinical range using validated cutoffs. We combined all adjusted area-specific effect estimates using random-effects meta-analysis and multiple imputations and applied inverse probability-weighting methods to correct for loss to follow-up. Results: We classified a total of 2, 801 children as having ADHD symptoms within the borderline/clinical range, and 1, 590 within the clinical range. Exposure to air pollution during pregnancy was not associated with a higher odds of ADHD symptoms within the borderline/clinical range (e.g., adjusted odds ratio [OR] for ADHD symptoms of 0.95, 95% confidence interval [CI] = 0.89, 1.01 per 10 µg/m 3 increase in NO2 and 0.98, 95% CI = 0.80, 1.19 per 5 µg/m 3 increase in PM2.5 ). We observed similar associations for ADHD within the clinical range. Conclusions: There was no evidence for an increase in risk of ADHD symptoms with increasing prenatal air pollution levels in children aged 3–10 years. See video abstract at, http://links.lww.com/EDE/B379 . Abstract : Supplemental Digital Content is available in the text. … (more)
- Is Part Of:
- Epidemiology. Volume 29:Issue 5(2018)
- Journal:
- Epidemiology
- Issue:
- Volume 29:Issue 5(2018)
- Issue Display:
- Volume 29, Issue 5 (2018)
- Year:
- 2018
- Volume:
- 29
- Issue:
- 5
- Issue Sort Value:
- 2018-0029-0005-0000
- Page Start:
- Page End:
- Publication Date:
- 2018-09
- Subjects:
- attention deficit disorder with hyperactivity -- child development -- environmental pollution -- longitudinal studies -- meta-analysis -- nitrogen oxides -- particulate matter -- prospective studies
Epidemiology -- Periodicals
Epidemiology -- Environmental aspects -- Periodicals
Epidemiology -- Periodicals
614.405 - Journal URLs:
- http://journals.lww.com ↗
http://journals.lww.com/epidem/Pages/default.aspx ↗ - DOI:
- 10.1097/EDE.0000000000000874 ↗
- Languages:
- English
- ISSNs:
- 1044-3983
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3793.574000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 10737.xml