Efficacy of Modified Dose-dense Paclitaxel in Recurrent Cervical Cancer. (September 2018)
- Record Type:
- Journal Article
- Title:
- Efficacy of Modified Dose-dense Paclitaxel in Recurrent Cervical Cancer. (September 2018)
- Main Title:
- Efficacy of Modified Dose-dense Paclitaxel in Recurrent Cervical Cancer
- Authors:
- Machida, Hiroko
Moeini, Aida
Ciccone, Marcia A.
Mostofizadeh, Sayedamin
Takiuchi, Tsuyoshi
Brunette, Laurie L.
Roman, Lynda D.
Matsuo, Koji - Abstract:
- Abstract : Objective: To examine survival outcomes of women with recurrent cervical cancer who received salvage chemotherapy with modified dose-dense paclitaxel (MDDP) monotherapy (paclitaxel 80 mg/m 2, administered on day 1, 8, and 15 without day 22). Materials and Methods: A retrospective study was conducted to evaluate cause-specific survival after the first recurrence (SAR) of women with recurrent cervical cancer diagnosed between 2006 and 2014. Pooled analyses were performed to examine SAR in women who received MDDP monotherapy (n=17) for any treatment line, compared with those who received salvage chemotherapy with paclitaxel-doublet (n=18) and nonpaclitaxel regimens (n=52). Results: In the whole cohort, median SAR was 13.7 months including 63 (72.4%) events. MDDP monotherapy regimen was most commonly used in the second-line setting (35.3%) followed by the third/fourth lines (both, 23.5%). Among the women who received MDDP regimen, there were 6 (35.3%) women who received ≥6 cycles; there was 1 (5.9%) women who discontinued the regimen due to adverse effects (grade 3 transaminitis); regimen postponement was seen in 2 (1.4%) of 140 total cycles; and the response rate after the sixth cycle of this regimen was 29.4% (1 complete and 4 partial responses). On univariate analysis, MDDP usage had the highest 2-year SAR rate (MDDP 54.1%, paclitaxel-doublet 43.6%, and nonpaclitaxel regimens 28.1%; P trend =0.044). On multivariate analysis, MDDP monotherapy remained an independentAbstract : Objective: To examine survival outcomes of women with recurrent cervical cancer who received salvage chemotherapy with modified dose-dense paclitaxel (MDDP) monotherapy (paclitaxel 80 mg/m 2, administered on day 1, 8, and 15 without day 22). Materials and Methods: A retrospective study was conducted to evaluate cause-specific survival after the first recurrence (SAR) of women with recurrent cervical cancer diagnosed between 2006 and 2014. Pooled analyses were performed to examine SAR in women who received MDDP monotherapy (n=17) for any treatment line, compared with those who received salvage chemotherapy with paclitaxel-doublet (n=18) and nonpaclitaxel regimens (n=52). Results: In the whole cohort, median SAR was 13.7 months including 63 (72.4%) events. MDDP monotherapy regimen was most commonly used in the second-line setting (35.3%) followed by the third/fourth lines (both, 23.5%). Among the women who received MDDP regimen, there were 6 (35.3%) women who received ≥6 cycles; there was 1 (5.9%) women who discontinued the regimen due to adverse effects (grade 3 transaminitis); regimen postponement was seen in 2 (1.4%) of 140 total cycles; and the response rate after the sixth cycle of this regimen was 29.4% (1 complete and 4 partial responses). On univariate analysis, MDDP usage had the highest 2-year SAR rate (MDDP 54.1%, paclitaxel-doublet 43.6%, and nonpaclitaxel regimens 28.1%; P trend =0.044). On multivariate analysis, MDDP monotherapy remained an independent prognostic factor for improved SAR compared with the nonpaclitaxel regimen (adjusted-hazard ratio, 0.50; 95% confidence interval, 0.26-0.95; P =0.036). Conclusion: Our results suggested that MDDP monotherapy is a tolerable and relatively effective regimen for recurrent cervical cancer. Abstract : Supplemental Digital Content is available in the text. … (more)
- Is Part Of:
- American journal of clinical oncology. Volume 41:Number 9(2018)
- Journal:
- American journal of clinical oncology
- Issue:
- Volume 41:Number 9(2018)
- Issue Display:
- Volume 41, Issue 9 (2018)
- Year:
- 2018
- Volume:
- 41
- Issue:
- 9
- Issue Sort Value:
- 2018-0041-0009-0000
- Page Start:
- Page End:
- Publication Date:
- 2018-09
- Subjects:
- cervical cancer -- recurrence -- paclitaxel -- dose-dense chemotherapy
Cancer -- Treatment -- Periodicals
Oncology -- Periodicals
Tumors -- Periodicals
616.994005 - Journal URLs:
- http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=toc&D=yrovft&AN=00000421-000000000-00000 ↗
http://www.amjclinicaloncology.com ↗
http://journals.lww.com ↗ - DOI:
- 10.1097/COC.0000000000000394 ↗
- Languages:
- English
- ISSNs:
- 0277-3732
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0823.500000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 10742.xml