Long-Term Survivors of Pancreatic Cancer: A California Population-Based Study. Issue 8 (September 2018)

• Record Type: Journal Article
• Authors: Kardosh, Adel; Lichtensztajn, Daphne Y.; Gubens, Matthew A.; Kunz, Pamela L.; Fisher, George A.; Clarke, Christina A.
• Is Part Of: Pancreas. Volume 47:Issue 8(2018)
• Publication Date: 2018-09
• Subjects: pancreatic adenocarcinoma -- long-term survival -- surgical resection -- chemotherapy -- differentiation -- race/ethnicity; Pancreas -- Diseases -- Periodicals; Pancreas -- Periodicals; Neuroendocrine tumors -- Periodicals; 616.37005
• DOI: 10.1097/MPA.0000000000001133
• Languages: English
• ISSNs: 0885-3177

Abstract

Abstract : Objectives: Pancreatic cancer continues to carry a poor prognosis with survival rates that have had minimal improvement over the past 4 decades. We report a population-based, comprehensive analysis of long-term survivors of pancreatic adenocarcinoma diagnosed in the diverse population of California. Methods: Data from the California Cancer Registry were used to evaluate long-term survival. A total of 70, 442 patients diagnosed with pancreatic adenocarcinoma between 1988 and 2009 were identified. Logistic regression was used to identify factors associated with achieving 5-year survival. Results: The overall 5-year survival was 2.5%, with minimal incremental improvements throughout the 3 decades. Age, stage, degree of differentiation, and surgical resection were associated with 5-year survival. Furthermore, younger age and receiving care at a National Cancer Institute–designated cancer center were similarly correlated with 5-year survival regardless of surgical intervention. In addition, we identified stage, differentiation, and adjuvant chemotherapy as significant factors for long-term survival in surgically resected patients. In the unresectable patients, Asian/Pacific islanders and Hispanics were significantly more likely to reach the 5-year milestone than non-Hispanic whites. Conclusions: Although pancreatic cancer mortality remains high, our study highlights baseline characteristics, treatment, biological factors, and ethnicity that are associated with long-term survival. These findings may serve as a springboard for further investigation. Abstract : Supplemental digital content is available in the text.