Developmental trajectories of macroanatomical structures in common marmoset brain. (19th November 2017)

• Record Type: Journal Article
• Authors: Seki, Fumiko; Hikishima, Keigo; Komaki, Yuji; Hata, Junichi; Uematsu, Akiko; Okahara, Norio; Yamamoto, Masafumi; Shinohara, Haruka; Sasaki, Erika; Okano, Hideyuki
• Is Part Of: Neuroscience. Volume 364(2017)
• Page Start: 143
• Page End: 156
• Publication Date: 2017-11-19
• Subjects: GM gray matter -- mPFC medial prefrontal cortex -- MRI magnetic resonance imaging -- PCR polymerase chain reaction -- T1WI T1-weighted images -- V1 primary visual cortex -- WM white matter; brain development -- common marmoset -- cortex -- growth trajectory -- longitudinal MRI -- non-human primate; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2017.09.021
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: We longitudinally investigated developmental patterns of global and cortical brain in common marmoset. Gray matter volume increases before the puberty and declines thereafter, whereas white matter volume continues to increase. Timing of volume peak and degree of decline vary by cortical region. Developmental age-specific brain templates are available. Abstract: Morphometry studies of human brain development have revealed characteristics of some growth patterns, such as gray matter (GM) and white matter (WM), but the features that make human neurodevelopment distinct from that in other species remain unclear. Studies of the common marmoset ( Callithrix jacchus ), a small New World primate, can provide insights into unique features such as cooperative behaviors complementary to those from comparative analyses using mouse and rhesus monkey. In the present study, we analyzed developmental patterns of GM, WM, and cortical regions with volume measurements using longitudinal sample (23 marmosets; 11 male, 12 female) between the ages of one and 30 months. Regional analysis using a total of 164 magnetic resonance imaging datasets revealed that GM volume increased before puberty (5.4 months), but subsequently declined until adulthood, whereas WM volume increased rapidly before stabilizing around puberty (9.9 months). Cortical regions showed similar patterns of increase and decrease, patterns with global GM but differed in the timing of volume peak and degree of decline across regions. The progressive–regressive pattern detected in both global and cortical GM was well correlated to phases of synaptogenesis and synaptic pruning reported in previous marmoset studies. A rapid increase in WM in early development may represent a distinctive aspect of human neurodevelopment. These findings suggest that studies of marmoset brain development can provide valuable comparative information that will facilitate a deeper understanding of human brain growth and neurodevelopmental disorders.