Integrins promote axonal regeneration after injury of the nervous system. (15th February 2018)

• Record Type: Journal Article
• Authors: Nieuwenhuis, Bart; Haenzi, Barbara; Andrews, Melissa R.; Verhaagen, Joost; Fawcett, James W.
• Is Part Of: Biological reviews. Volume 93:Number 3(2018)
• Page Start: 1339
• Page End: 1362
• Publication Date: 2018-02-15
• Subjects: axon regeneration -- integrin -- kindlin -- receptor activation state -- selective polarised transport -- traumatic injury of the nervous system; Biology -- Periodicals; 570
• DOI: 10.1111/brv.12398
• Languages: English
• ISSNs: 1464-7931

Abstract

ABSTRACT: Integrins are cell surface receptors that form the link between extracellular matrix molecules of the cell environment and internal cell signalling and the cytoskeleton. They are involved in several processes, e.g. adhesion and migration during development and repair. This review focuses on the role of integrins in axonal regeneration. Integrins participate in spontaneous axonal regeneration in the peripheral nervous system through binding to various ligands that either inhibit or enhance their activation and signalling. Integrin biology is more complex in the central nervous system. Integrins receptors are transported into growing axons during development, but selective polarised transport of integrins limits the regenerative response in adult neurons. Manipulation of integrins and related molecules to control their activation state and localisation within axons is a promising route towards stimulating effective regeneration in the central nervous system.