Evaluation of appendicular lean mass using bio impedance in persons aged 80+: A new equation based on the BUTTERFLY-study. Issue 4 (August 2019)

• Record Type: Journal Article
• Authors: Vermeiren, S.; Beckwée, D.; Vella-Azzopardi, R.; Beyer, I.; Knoop, V.; Jansen, B.; Delaere, A.; Antoine, A.; Bautmans, I.; Scafoglieri, A.
• Is Part Of: Clinical nutrition. Volume 38:Issue 4(2019)
• Page Start: 1756
• Page End: 1764
• Publication Date: 2019-08
• Subjects: Body composition -- Sarcopenia -- Bioelectrical impedance analysis -- Dual X-ray absorptiometry -- Aged 80 and over; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2018.07.029
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background: To date, the accuracy of bio-impedance (BIA) to assess body composition & sarcopenia in persons aged 80 and over remains unclear. Objective: We aimed to evaluate the agreement between dual energy X-ray absorptiometry (DXA) and BIA equations to determine lean mass, as well as their suitability to identify sarcopenia. Design: 174 community dwelling well-functioning persons (83 women, 91 men) aged 80 and over were included. Appendicular lean mass (ALM) was predicted using BIA-based equations available in literature, and compared to DXA outcomes. Through cross-validation and stepwise multiple linear regression, a new ALM-formula was generated suitable for this population. Results: Literature-based BIA equations systematically overestimated ALM. The new prediction formula that we propose for the 80+ is: ALM = 0, 827+(0, 19*Impedance Index)+(2, 101*Sex)+(0, 079*Weight); R 2 = 0, 888; SEE = 1, 450 kg. Sarcopenia classification based on our new BIA equation for ALM showed better agreement with DXA (k ≥ 0, 454) compared to literature-based BIA equations (k < 0, 368). Conclusions: Despite the high correlation between both methods, literature-based BIA equations consistently overestimate ALM compared to DXA in persons aged 80 and over. We proposed a new equation for ALM, reaching higher agreement with DXA and thus improving the accuracy of BIA for this specific age group.