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Upregulation of endogenous thrombopoietin receptor (MPL) with in vivo passage of calreticulin (CALR) mutant Ba/F3 cells, highlighting MPL as the requisite cytokine receptor for CALR mediated transformation. (July 2019)
Record Type:
Journal Article
Title:
Upregulation of endogenous thrombopoietin receptor (MPL) with in vivo passage of calreticulin (CALR) mutant Ba/F3 cells, highlighting MPL as the requisite cytokine receptor for CALR mediated transformation. (July 2019)
Main Title:
Upregulation of endogenous thrombopoietin receptor (MPL) with in vivo passage of calreticulin (CALR) mutant Ba/F3 cells, highlighting MPL as the requisite cytokine receptor for CALR mediated transformation
Highlights: in vivo passage of calreticulin mutant Ba/F3 cells leads to cytokine independence. These cells expanding in mice have upregulation of endogenous MPL. MPL is the requisite cytokine receptor for calreticulin mediated transformation.