Effect of substrate competition in kinetic models of metabolic networks. Issue 17 (26th June 2013)

• Record Type: Journal Article
• Authors: Schäuble, Sascha; Stavrum, Anne Kristin; Puntervoll, Pål; Schuster, Stefan; Heiland, Ines
• Is Part Of: FEBS letters. Volume 587:Issue 17(2013)
• Page Start: 2818
• Page End: 2824
• Publication Date: 2013-06-26
• Subjects: Substrate competition -- Kinetic rate laws -- Modelling -- Metabolic pathway; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2013.06.025
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Substrate competition can be found in many types of biological processes, ranging from gene expression to signal transduction and metabolic pathways. Although several experimental and in silico studies have shown the impact of substrate competition on these processes, it is still often neglected, especially in modelling approaches. Using toy models that exemplify different metabolic pathway scenarios, we show that substrate competition can influence the dynamics and the steady state concentrations of a metabolic pathway. We have additionally derived rate laws for substrate competition in reversible reactions and summarise existing rate laws for substrate competition in irreversible reactions.