Minireview: pH and synaptic transmission. Issue 13 (10th May 2013)

• Record Type: Journal Article
• Authors: Sinning, Anne; Hübner, Christian A.
• Is Part Of: FEBS letters. Volume 587:Issue 13(2013)
• Page Start: 1923
• Page End: 1928
• Publication Date: 2013-05-10
• Subjects: pH regulation -- Ion transporter -- Mouse model -- Carbonic anhydrase -- Synaptic transmission -- GABA -- Neuronal excitability; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2013.04.045
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : As a general rule a rise in pH increases neuronal activity, whereas it is dampened by a fall of pH. Neuronal activity per se also challenges pH homeostasis by the increase of metabolic acid equivalents. Moreover, the negative membrane potential of neurons promotes the intracellular accumulation of protons. Synaptic key players such as glutamate receptors or voltage‐gated calcium channels show strong pH dependence and effects of pH gradients on synaptic processes are well known. However, the processes and mechanisms that allow controlling the pH in synaptic structures and how these mechanisms contribute to normal synaptic function are only beginning to be resolved.