Immune and genetic gardening of the intestinal microbiome. Issue 22 (5th March 2014)

• Record Type: Journal Article
• Authors: Jacobs, Jonathan P.; Braun, Jonathan
• Is Part Of: FEBS letters. Volume 588:Issue 22(2014)
• Page Start: 4102
• Page End: 4111
• Publication Date: 2014-03-05
• Subjects: Intestine -- Epithelium -- Immune system -- Mucosal immunology -- Microbial ecology -- Inflammatory bowel disease -- Crohn's disease -- Ulcerative colitis -- Pattern recognition receptor -- Innate lymphoid cell -- Microbiome; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2014.02.052
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : The mucosal immune system – consisting of adaptive and innate immune cells as well as the epithelium – is profoundly influenced by its microbial environment. There is now growing evidence that the converse is also true, that the immune system shapes the composition of the intestinal microbiome. During conditions of health, this bidirectional interaction achieves a homeostasis in which inappropriate immune responses to non‐pathogenic microbes are averted and immune activity suppresses blooms of potentially pathogenic microbes (pathobionts). Genetic alteration in immune/epithelial function can affect host gardening of the intestinal microbiome, contributing to the diversity of intestinal microbiota within a population and in some cases allowing for unfavorable microbial ecologies (dysbiosis) that confer disease susceptibility.