Development and regulation of RORγt+ innate lymphoid cells. Issue 22 (26th March 2014)

• Record Type: Journal Article
• Authors: Cording, Sascha; Medvedovic, Jasna; Cherrier, Marie; Eberl, Gérard
• Is Part Of: FEBS letters. Volume 588:Issue 22(2014)
• Page Start: 4176
• Page End: 4181
• Publication Date: 2014-03-26
• Subjects: Innate lymphoid cells -- Mucosal immunity -- RORγt -- IL-22; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2014.03.034
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : RORγt + innate lymphoid cells (ILCs), or ILC3, play a fundamental role in the development of lymphoid tissues, as well as in homeostasis and defence of mucosal tissues. These cells produce IL‐22, IL‐17A and LTα1β2, key cytokines for the activation of epithelial defences and the recruitment of polymorphonuclear phagocytes. In the absence of ILC3, the early defence to infection and resistance to injury are compromised. Given the importance of ILC3 in mucosal immunity, significant efforts are made to discover their multiple functions and decipher their mode of action and regulation.