Membrane microdomains in immunoreceptor signaling. Issue 15 (6th June 2014)

• Record Type: Journal Article
• Authors: Horejsi, Vaclav; Hrdinka, Matous
• Is Part Of: FEBS letters. Volume 588:Issue 15(2014)
• Page Start: 2392
• Page End: 2397
• Publication Date: 2014-06-06
• Subjects: Lipid raft -- Leukocyte -- Immunoreceptor signaling; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2014.05.047
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Membrane microdomains denoted commonly as lipid rafts (or membrane rafts) have been implicated in T‐cell receptor (TCR), and more generally immunoreceptor, signaling for over 25 years. However, this area of research has been complicated by doubts about the real nature (and even existence) of these membrane entities, especially because of methodological problems connected with possible detergent artefacts. Recent progress in biophysical approaches and functional studies of raft resident proteins apparently clarified many controversial aspects in this area. At present, the prevailing view is that these membrane microdomains are indeed involved in many aspects of cell biology, including immunoreceptor signaling. Moreover, several other types of raft‐like microdomains (perhaps better termed nanodomains) have been described, which apparently also play important biological roles.