Blood eosinophils and serum eosinophil cationic protein in patients with acute and chronic urticaria. Issue 2 (1996)

• Record Type: Journal Article
• Authors: Lorenzo Lorenzo, G. Di G. Di; Mansueto Mansueto, P. P.; Melluso Melluso, M. M.; Candore Candore, G. G.; Cigna Cigna, D. D.; Pellitteri Pellitteri, M. E. M. E.; Salvo Salvo, A. Di A. Di; Caruso Caruso, C. C.
• Is Part Of: Mediators of inflammation. Volume 5:Issue 2(1996)
• Page Start: 113
• Page End: 115
• Publication Date: 1996
• Subjects: Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1155/S0962935196000191
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : We have analysed the relationship of blood eosinophil count and serum eosinophil cationic protein (ECP) levels in patients with acute and chronic idiopathic urticaria. The ECP levels and eosinophil counts were measured in the peripheral blood of 15 patients with acute urticaria, 25 with chronic idiopathic urticaria and 10 normal healthy subjects. Blood eosinophil counts and serum ECP levels increased in all patients with acute urticaria. Concerning patients affected by chronic urticaria, taking into account the recrudescence of the disease at the moment of taking the blood sample, only symptomatic patients showed increased eosinophil blood values whereas serum ECP levels were increased both in symptomatic and asymptomatic patients. Furthermore, serum ECP levels in chronic urticaria did not correlate with the peripheral eosinophil counts, as they did in acute urticaria. The results of the present study indicate that eosinophils may play a role in the inflammatory mechanisms in patients with acute and chronic urticaria showing a positive correlation between serum ECP levels and disease activity.