Tailored Microstructured Hyperpolarizing Matrices for Optimal Magnetic Resonance Imaging. (15th March 2018)

• Record Type: Journal Article
• Authors: Cavaillès, Matthieu; Bornet, Aurélien; Jaurand, Xavier; Vuichoud, Basile; Baudouin, David; Baudin, Mathieu; Veyre, Laurent; Bodenhausen, Geoffrey; Dumez, Jean‐Nicolas; Jannin, Sami; Copéret, Christophe; Thieuleux, Chloé
• Is Part Of: Angewandte Chemie. Volume 130:Number 25(2018)
• Page Start: 7575
• Page End: 7579
• Publication Date: 2018-03-15
• Subjects: Dynamische Kernpolarisation -- Hyperpolarisation -- Kernspintomographie -- Kieselgel -- Sol-Gel-Prozesse; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201801009
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Tailoring the physical features and the porous network architecture of silica‐based hyperpolarizing solids containing TEMPO radicals, known as HYPSO (hybrid polarizing solids), enabled unprecedented performance of dissolution dynamic nuclear polarization ( d ‐DNP). High polarization values up to P ( 1 H)=99 % were reached for samples impregnated with a mixture of H2 O/D2 O and loaded in a 6.7 T polarizer at temperatures around 1.2 K. These HYPSO materials combine the best performance of homogeneous DNP formulations with the advantages of solid polarizing matrices, which provide hyperpolarized solutions free of any—potentially toxic—additives (radicals and glass‐forming agents). The hyperpolarized solutions can be expelled from the porous solids, filtered, and rapidly transferred either to a nuclear magnetic resonance (NMR) spectrometer or to a magnetic resonance imaging (MRI) system.