Regulated unfolding of proteins in signaling. Issue 8 (20th February 2013)

• Record Type: Journal Article
• Authors: Mitrea, Diana M.; Kriwacki, Richard W.
• Is Part Of: FEBS letters. Volume 587:Issue 8(2013)
• Page Start: 1081
• Page End: 1088
• Publication Date: 2013-02-20
• Subjects: IDP -- intrinsically disordered protein -- NLS -- nuclear localization signal -- NES -- nuclear export signal -- Regulated unfolding -- Signal transduction -- Protein dynamics -- Unfolding trigger -- Alternative protein fold -- NMR spectroscopy; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2013.02.024
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : The transduction of biological signals often involves structural rearrangements of proteins in response to input signals, which leads to functional outputs. This review discusses the role of regulated partial and complete protein unfolding as a mechanism of controlling protein function and the prevalence of this regulatory mechanism in signal transduction pathways. The principles of regulated unfolding, the stimuli that trigger unfolding, and the coupling of unfolding with other well characterized regulatory mechanism are discussed.