Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency. (7th July 2015)

• Record Type: Journal Article
• Authors: Anno, Masato; Yamazaki, Takashi; Hara, Nobuhiro; Hayakawa, Keishi
• Other Names: Modi Hitesh N. Academic Editor.
• Is Part Of: Case reports in orthopedics. Volume 2015(2015)
• Publication Date: 2015-07-07
• Subjects: Orthopedics -- Periodicals; Orthopedics; Orthopedics; Periodicals; Electronic journals; Periodicals; 616.7
• DOI: 10.1155/2015/536592
• Languages: English
• ISSNs: 2090-6749

Abstract

Abstract : A 71-year-old man underwent cervical laminectomy and developed two symptomatic epidural hematomas during the acute postoperative period. On both occasions, drain obstruction was the predominant cause. Congenital Protein S deficiency was diagnosed postoperatively. Protein S is a vitamin K-dependent natural anticoagulant and is essential for inhibiting thrombosis in microcirculation. We assume that Protein S deficiency followed by perioperative bed-rest and surgical invasiveness led to severe hypercoagulability and subsequent drain obstruction. The present findings suggest that both bleeding disorders and hypercoagulability are risk factors for postoperative symptomatic epidural hematoma.