In vitro antiplasmodial and cytotoxic activities of sesquiterpene lactones from Vernonia fimbrillifera Less. (Asteraceae). Issue 12 (18th June 2018)

• Record Type: Journal Article
• Authors: Bordignon, Annélise; Frédérich, Michel; Ledoux, Allison; Campos, Pierre-Eric; Clerc, Patricia; Hermann, Thomas; Quetin-Leclercq, Joëlle; Cieckiewicz, Ewa
• Is Part Of: Natural product research. Volume 32:Issue 12(2018)
• Page Start: 1463
• Page End: 1466
• Publication Date: 2018-06-18
• Subjects: Antiplasmodial activity -- sesquiterpene lactones -- Vernonia fimbrillifera Less -- Asteraceae -- Reunion Island; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1350665
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Due to the in vitro antiplasmodial activity of leaf extracts from Vernonia fimbrillifera Less. (Asteraceae), a bioactivity-guided fractionation was carried out. Three sesquiterpene lactones were isolated, namely 8-(4'-hydroxymethacrylate)-dehydromelitensin (1 ), onopordopicrin (2 ) and 8α-[4'-hydroxymethacryloyloxy]-4-epi-sonchucarpolide (3 ). Their structures were elucidated by spectroscopic methods (1D and 2D NMR and MS analyses) and by comparison with published data. The isolated compounds exhibited antiplasmodial activity with IC50 values ≤ 5 μg/mL. Cytotoxicity of the compounds against a human cancer cell line (HeLa) and a mouse lung epithelial cell line (MLE12) was assessed to determine selectivity. Compound3 displayed promising selective antiplasmodial activity (SI > 10). Abstract :