Acetyl- and O-alkyl- derivatives of β-mangostin from Garcinia mangostana and their anti-inflammatory activities. Issue 12 (18th June 2018)

• Record Type: Journal Article
• Authors: Karunakaran, Thiruventhan; Ee, Gwendoline Cheng Lian; Ismail, Intan Safinar; Mohd Nor, Siti Mariam; Zamakshshari, Nor Hisam
• Is Part Of: Natural product research. Volume 32:Issue 12(2018)
• Page Start: 1390
• Page End: 1394
• Publication Date: 2018-06-18
• Subjects: Acetyl- and O-alkyl- β-mangostin -- anti-inflammation -- β-mangostin; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1350666
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Pure β-mangostin (1) was isolated from the stem bark of Garcinia mangostana L. One monoacetate (2 ) and five O -alkylated β-mangostin derivatives (3–7 ) were synthesised from β-mangostin. The structures of these compounds were elucidated and determined using spectroscopic techniques such as 1D NMR and MS. The cytotoxicities and anti-inflammatory activities of these five compounds against RAW cell 264.7 were tested. The structural-activity relationship studies indicated that β-mangostin showed a significant activity against the LPS-induced RAW cell 264.7, while the acetyl- as well as the O -alkyl- β-mangostin derivatives did not give good activity. Naturally occurring β-mangostin demonstrated comparatively better anti-inflammatory activity than its synthetic counterparts. Abstract :