Effect of QiShenYiQi Pill on Myocardial Collagen Metabolism in Rats with Partial Abdominal Aortic Coarctation. (11th March 2015)

• Record Type: Journal Article
• Authors: Lv, Shichao; Wu, Meifang; Li, Meng; Wang, Qiang; Wang, Xiaojing; Xu, Ling; Zhang, Junping
• Other Names: Tsim Karl Wah-Keung Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2015(2015)
• Publication Date: 2015-03-11
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2015/415068
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : This study investigated the effect of QiShenYiQi pill (QSYQ) on myocardial collagen metabolism in rats with partial abdominal aortic coarctation and explored its mechanism of action. A series of assays were used to detect the effect and mechanism of QSYQ on systolic blood pressure, heart mass index, left ventricle mass index, HYP, expression of PICP, PIIINT, and CTX-I in serum, MMP-1, and TIMP-1 expression in myocardium. We observed that QSYQ can reduce the rate of myocardial collagen synthesis and increase the rate of myocardial collagen degradation. It also effectively improved the degree of myocardial fibrosis in partial abdominal aortic rats and it had a tendency to have a greater effect with longer treatment duration, which is related to the mechanism of regulation of MMP-1 and TIMP-1 expression in the myocardial rat.