Plan quality and robustness in field junction region for craniospinal irradiation with VMAT. (April 2018)

• Record Type: Journal Article
• Authors: Wang, Keqiang; Meng, Huipeng; Chen, Jie; Zhang, Wenxue; Feng, Yuanming
• Is Part Of: Physica medica. Volume 48(2018)
• Page Start: 21
• Page End: 26
• Publication Date: 2018-04
• Subjects: CSI -- VMAT -- Robustness -- Staggered overlap; Medical physics -- Periodicals; Biophysics -- Periodicals; Biophysics -- Periodicals; Imagerie médicale -- Périodiques; Radiothérapie -- Périodiques; Rayons X -- Sécurité -- Mesures -- Périodiques; Physique -- Périodiques; Médecine -- Périodiques; 610.153
• DOI: 10.1016/j.ejmp.2018.03.007
• Languages: English
• ISSNs: 1120-1797

Abstract

Graphical abstract: Highlights: Plan quality and robustness need to be considered for craniospinal irradiation. "Overlap" technique is not always effective in plan robustness. "Gradient optimization" approach is labor intensive and poor in plan quality. "Staggered overlap" technique provides better plan quality and robustness. Abstract: Purpose: To propose a "staggered overlap" technique in volumetric modulated arc therapy (VMAT) for craniospinal irradiation (CSI) and compare the dose distribution and plan robustness with "overlap" technique and "gradient optimization" approach. Methods and Materials: 6 patients previously treated in our clinic were retrospectively selected. 9 VMAT plans of each patient were optimized with "staggered overlap", "overlap" and "gradient optimization" in overlapping region of 3 cm, 6 cm, and 9 cm separately. For the "staggered overlap" plan, adjacent field sets were intentionally overlapped by staggering field edges in an appropriate step size to avoid sharp dose gradient. Evaluation metrics including V95%, D2%, D98%, conformity number (CN) and homogeneity index (HI) were employed to evaluate the dose distribution. Moreover, shifts of the upper spinal field isocenter in each direction were performed to simulate junction errors for robustness analysis. Results: The CN and HI of VMAT plans with "staggered overlap" were 0.82 (0.811–0.822) and 0.113 (0.112–0.114), while they were 0.778 (0.776–0.782) and 0.131 (0.130–0.131) for plans with "gradient optimization". In the robustness study, <3% dose deviations were found for 5 mm shifts in lateral and vertical directions with all techniques. In cranial-caudal direction, "overlap" technique created hot spots (D2% > 170%) and cold spots (D98% < 44%) in the junction region with 10 mm shifts. The dose deviations were decreased to 22% for plans with "staggered overlap" and 9 cm overlapping region. Conclusion: "Staggered overlap" technique provides better plan quality as compared to "gradient optimization" approach and makes the plan more robust against junction errors as compared to "overlap" technique.