Circulating Levels of Soluble Receptor Activator of NF-κB Ligand and Matrix Metalloproteinase 3 (and Their Antagonists) in Asian Indian Patients with Ankylosing Spondylitis. (1st September 2013)

• Record Type: Journal Article
• Authors: Dhir, Varun; Srivastava, Rajni; Aggarwal, Amita
• Other Names: van Vollenhoven Ronald F. Academic Editor.
• Is Part Of: International journal of rheumatology. Volume 2013(2013)
• Publication Date: 2013-09-01
• Subjects: Rheumatology -- Periodicals; Rheumatology; Rheumatology; Electronic journals; Periodicals; Periodicals; 616.723
• DOI: 10.1155/2013/814350
• Languages: English
• ISSNs: 1687-9260

Abstract

Abstract : Background . Bone loss in ankylosing spondylitis may be related to inflammation. Data from previous studies on circulating levels of sRANKL, OPG, MMP3, and TIMP is inconsistent; thus this study is planned to look at this aspect in Asian Indian patients. Methods . Cross-sectional study included patients with ankylosing spondylitis and age- and gender-similar controls. Serum levels of sRANKL, OPG, MMP-3, and TIMP-1 were measured by ELISA. Results . Included 85 patients (M : F = 82 : 3) having mean age (±SD)33 . 0 ± 10 . 0 years and disease duration11 . 3 ± 7.3 years. BASDAI, BASFI, BASMI, and ESR were4 . 0 ± 2.2, 3 . 9 ± 2.8, 3 . 0 ± 2.8, and59 . 2 ± 31.2, respectively. Patients had higher mean (±SD) OPG level (649 . 7 ± 286.8, 389 . 3 ± 244.8 pg/mL, P < 0.001 ). However, there was no difference in sRANKL (349 . 2 ± 872.0, 554 . 7 ± 1850.1, P = n s ). Serum MMP-3 (91 . 4 ± 84.7, 55 . 9 ± 37.1 ng/mL, P < 0.01 ) and TIMP-1 (520 . 6 ± 450.7, 296 . 5 ± 114.2 ng/mL, P < 0.001 ) levels were higher in patients; however, there was no difference in MMP-3/TIMP-1 ratio. Conclusion . Circulating levels of OPG were higher; however, there was no difference in sRANKL in Asian Indian ankylosing spondylitis patients. Although both MMP-3 and TIMP-1 were raised, their ratio was not different from that of controls.