Successful Utilization of High-Flux Hemodialysis for Treatment of Vancomycin Toxicity in a Child. (29th January 2012)

• Record Type: Journal Article
• Authors: Stidham, Timothy; Reiter, Pamela D.; Ford, Douglas M.; Lum, Gary M.; Albietz, Joseph
• Other Names: Arslan N. Academic Editor.; Fischer D. Academic Editor.
• Is Part Of: Case reports in pediatrics. Volume 2011(2011)
• Publication Date: 2012-01-29
• Subjects: Pediatrics -- Periodicals; Pediatrics; Pediatrics; Electronic journals; Periodicals; Case Reports; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 618.92
• DOI: 10.1155/2011/678724
• Languages: English
• ISSNs: 2090-6803

Abstract

Abstract : Vancomycin is routinely used for empiric antibiotic therapy in children. Higher-serum-concentration targets for serious infections are now being recommended. This recommendation may result in aggressive dosing with increased potential for toxicity. We report a case of a pediatric patient who developed vancomycin toxicity and associated oliguric renal failure who was treated effectively with high-flux hemodialysis for vancomycin toxicity, clearing serum concentrations of vancomycin by over 75% in only 6 hours (213.2 mcg/mL to 51.8 mcg/mL) with subsequent return to baseline renal function and without adverse sequelae. While not historically considered a viable option for drug removal in cases of toxicity, new high-flux hemodialysis techniques can remove significant percentages of vancomycin in short periods of time.