Prevalence and Risk Factors for Hypertrophic Scarring of Split Thickness Autograft Donor Sites in a Pediatric Burn Population. Issue 5 (August 2019)

• Record Type: Journal Article
• Authors: Rotatori, R. Maxwell; Starr, Brian; Peake, Mitchell; Fowler, Laura; James, Laura; Nelson, Judy; Dale, Elizabeth L.
• Is Part Of: Burns. Volume 45:Issue 5(2019)
• Page Start: 1066
• Page End: 1074
• Publication Date: 2019-08
• Subjects: Hypertrophic scarring -- donor site -- pediatric -- skin graft -- autograft; Burns and scalds -- Periodicals; 617.11
• DOI: 10.1016/j.burns.2019.02.003
• Languages: English
• ISSNs: 0305-4179

Abstract

Highlights: 1/3 of patients to never experience hypertrophic scarring of their donor sites. 1/3 of patients have donor site hypertrophic scarring that resolved. 1/3 of patients have hypertrophic scarring that persisted. Re-epithelialization time, %TBSA, harvest depth increase hypertrophic scarring risk. Abstract: Title: Prevalence and Risk Factors for Hypertrophic Scarring of Split Thickness Autograft Donor Sites in a Pediatric Burn Population. Objective: The split-thickness autograft remains a fundamental treatment for burn injuries; however, donor sites may remain hypersensitive, hyperemic, less pliable, and develop hypertrophic scarring. This study sought to assess the long-term scarring of donor sites after pediatric burns. Methods: A retrospective review of pediatric burn patients treated at a single institution (2010–2016) was performed. Primary outcomes were prevalence of donor site hypertrophic scarring, scarring time course, and risk factor assessment. Results: 237 pediatric burn patients were identified. Mean age at burn was 7 yrs., mean %TBSA was 26% with 17% being Full Thickness. Mean follow-up was 2.4 yrs. Hypertrophic scarring was observed in 152 (64%) patients with 81 (34%) patients having persistent hypertrophic scarring through long-term follow-up. Patient-specific risk factors for hypertrophic scarring were Hispanic ethnicity (P = 0.03), increased %TBSA (P = 0.03), %Full Thickness burn (P = 0.02) and total autograft amount (P = 0.03). Donor site factors for hypertrophic scarring were longer time to epithelialization (P < 0.0001), increased donor site harvest depth (P < 0.0001), autografts harvested in the acute burn setting (P = 0.008), and thigh donor site location (vs. all other sites; P < 0.0001). The scalp, arm, foot, and lower leg donor sites (vs. all other sites) were less likely to develop HTS (P < 0.0001, 0.02, 0.005, 0.002, respectively), along with a history of previous donor site harvest (P = 0.04). Conclusions: Hypertrophic scarring is a prominent burden in donor site wounds of pediatric burn patients. Knowledge of pertinent risk factors can assist with guiding management and expectations.