Photothermal Therapy: Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells (Adv. Mater. 23/2019). Issue 23 (3rd June 2019)

• Record Type: Journal Article
• Authors: Chen, Qian; Hu, Quanyin; Dukhovlinova, Elena; Chen, Guojun; Ahn, Sarah; Wang, Chao; Ogunnaike, Edikan A.; Ligler, Frances S.; Dotti, Gianpietro; Gu, Zhen
• Is Part Of: Advanced materials. Volume 31:Issue 23(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-06-03
• Subjects: CAR T cells -- cell therapy -- drug delivery -- immunotherapy -- photothermal therapy; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201970166
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : CAR‐T lymphocytes show modest therapeutic efficacy in solid tumors. Mild hyperthermia of the tumor reduces its compact structure and interstitial fluid pressure (IFP), increases blood perfusion, releases antigens, and promotes the recruitment of endogenous immune cells. In article number1900192, Gianpietro Dotti, Zhen Gu, and co‐workers find that CSPG4 ‐specific CAR‐T cells infused in NSG mice engrafted with the human melanoma WM115 cell line had superior antitumor activity after photothermal ablation of the tumor. These findings suggest that photothermal therapy facilitates the accumulation and effector function of CAR‐T cells within tumors.