Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings. (9th May 2017)

• Record Type: Journal Article
• Authors: Jacobs, Terry M.; Poehlmann, Cathy E.; Kiupel, Matti
• Other Names: Mutinelli Franco Academic Editor.
• Is Part Of: Case reports in veterinary medicine. Volume 2017(2017)
• Publication Date: 2017-05-09
• Subjects: Veterinary medicine -- Periodicals; Animals -- Diseases -- Periodicals; Animal health -- Periodicals; 636.08905
• DOI: 10.1155/2017/6952634
• Languages: English
• ISSNs: 2090-7001

Abstract

Abstract : This case report documents the clinical and pathological findings in a dog that rapidly developed a high-grade sarcoma at the site of multiple vaccinations and follows the response to surgery and adjunct treatment with toceranib. An 11-year-old female spayed Labrador Retriever presented with dorsocervical subcutaneous masses at the injection site three weeks after receiving DA2 PP-Lepto, Rabies, and Bordetella vaccinations. A high-grade soft tissue sarcoma was diagnosed microscopically and immunohistochemistry revealed positive expression of VEGFr, PDGFr, SCF, and EGFR. Repeat surgical resections and targeted treatment with toceranib resulted in a stable remission for nearly two years.