Use of benzodiazepine medications during pregnancy and potential risk for birth defects, National Birth Defects Prevention Study, 1997–2011. Issue 10 (19th March 2019)

• Record Type: Journal Article
• Authors: Tinker, Sarah C.; Reefhuis, Jennita; Bitsko, Rebecca H.; Gilboa, Suzanne M.; Mitchell, Allen A.; Tran, Emmy L.; Werler, Martha M.; Broussard, Cheryl S.
• Is Part Of: Birth defects research. Volume 111:Issue 10(2019)
• Page Start: 613
• Page End: 620
• Publication Date: 2019-03-19
• Subjects: benzodiazepine -- birth defect -- medication -- pregnancy; Teratology -- Periodicals; Abnormalities, Human -- Periodicals; Congenital Abnormalities; Embryo, Mammalian -- abnormalities; Teratology; Abnormalities, Human; Teratology; Periodicals; Periodicals; 616.043
• DOI: 10.1002/bdr2.1497
• Languages: English
• ISSNs: 2472-1727

Abstract

Abstract : Background: Benzodiazepine medications can be used to treat anxiety, a condition affecting 15% of women of childbearing age in the United States. Studies have shown conflicting results for the association between benzodiazepine use during pregnancy and birth defects. Methods: We analyzed 1997–2011 data from the National Birth Defects Prevention Study, a multisite, population‐based case–control study. We assessed the prevalence of and factors associated with benzodiazepine use in pregnancy among mothers of live‐born infants without a birth defect (control mothers). We used logistic regression to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for the association between specific birth defects and benzodiazepine use; we estimated crude odds ratios (cORs) for defect categories with 3–4 exposed cases. Results: Exposure to benzodiazepines during pregnancy was rare ( N = 93/11, 614; 0.8%). Benzodiazepine use was more common among control mothers who were ≥30 years, non‐Hispanic white, had more education, smoked, and took antidepressant medication. We observed significantly elevated ORs for any benzodiazepine and Dandy–Walker malformation (cOR: 3.1; 95% CI: 1.1, 8.6); for alprazolam and anophthalmia or microphthalmia (cOR: 4.0; 95% CI: 1.2, 13.1) and esophageal atresia or stenosis (aOR: 2.7; 95% CI: 1.2, 5.9); and lorazepam and pulmonary valve stenosis (cOR: 4.1; 95% CI: 1.2, 14.2), but sample sizes were limited and therefore CIs were wide. Conclusions: Our findings suggest that benzodiazepines use is rare and may be associated with risk for certain birth defects. However, these results need replication and should be interpreted with caution.