Adult Langerhans Cell Histiocytosis with Hepatic and Pulmonary Involvement. (21st April 2015)

• Record Type: Journal Article
• Authors: Araujo, Bruno; Costa, Francisco; Lopes, Joanne; Castro, Ricardo
• Other Names: Yalcin Suayib Academic Editor.
• Is Part Of: Case reports in radiology. Volume 2015(2015)
• Publication Date: 2015-04-21
• Subjects: Radiology -- Periodicals; Radiology -- Case studies -- Periodicals; Medical radiology -- Periodicals; Radiology; Radiology; Medical radiology; Periodicals; Electronic journals; Case studies; Periodicals; 616.0757
• DOI: 10.1155/2015/536328
• Languages: English
• ISSNs: 2090-6862

Abstract

Abstract : Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of Langerhans cells of unknown etiology. It can involve multiple organ systems with different clinical presentation, which complicates the diagnosis. It can range from isolated to multisystem disease with different prognosis. Although common among children, liver involvement is relatively rare in adults and frequently overlooked. Natural history of liver LCH fits into two stages: an early stage with infiltration by histiocytes and a late stage with sclerosis of the biliary tree. Pulmonary findings are more common and include multiple nodules in different stages of cavitation, predominantly in the upper lobes. We present a case of adult LCH with pulmonary and biopsy proven liver involvement with resolution of the hepatic findings after treatment.