Osteoprotegerin in Cardiometabolic Disorders. (11th May 2015)

• Record Type: Journal Article
• Authors: Pérez de Ciriza, C.; Lawrie, A.; Varo, N.
• Other Names: Iervasi Giorgio Academic Editor.
• Is Part Of: International journal of endocrinology. Volume 2015(2015)
• Publication Date: 2015-05-11
• Subjects: Endocrinology -- Periodicals; Endocrinology; Endocrinology -- Periodicals; Endocrine System Diseases -- Periodicals; Periodicals; 616.4
• DOI: 10.1155/2015/564934
• Languages: English
• ISSNs: 1687-8337

Abstract

Abstract : Osteoprotegerin (OPG), a glycoprotein traditionally implicated in bone remodelling, has been recently related to cardiovascular disease (CVD). Human studies show a positive relationship between circulating OPG, vascular damage, and CVD, and as such OPG has emerged as a potential biomarker for CVD. This review focuses on the relationship between circulating OPG and different endocrine cardiometabolic alterations such as type 1 and 2 diabetes. The association of OPG with diabetic complications (neuropathy, nephropathy, or retinopathy) as well as with atherosclerosis, coronary artery calcification, morbidity, and mortality is pointed out. Moreover, OPG modulation by different treatments is also established. Besides, other associated diseases such as obesity, hypertension, and metabolic syndrome, which are known cardiovascular risk factors, are also considered.