Cytokines in the Progression of Pancreatic β-Cell Dysfunction. (12th October 2010)

• Record Type: Journal Article
• Authors: Wang, Chunjiong; Guan, Youfei; Yang, Jichun
• Other Names: Henry Robert R. Academic Editor.
• Is Part Of: International journal of endocrinology. Volume 2010(2010)
• Publication Date: 2010-10-12
• Subjects: Endocrinology -- Periodicals; Endocrinology; Endocrinology -- Periodicals; Endocrine System Diseases -- Periodicals; Periodicals; 616.4
• DOI: 10.1155/2010/515136
• Languages: English
• ISSNs: 1687-8337

Abstract

Abstract : The dysfunction of pancreatic β -cell and the reduction in β -cell mass are the decisive events in the progression of type 2 diabetes. There is increasing evidence that cytokines play important roles in the procedure of β -cell failure. Cytokines, such as IL-1 β, IFN- γ, TNF- α, leptin, resistin, adiponectin, and visfatin, have been shown to diversely regulate pancreatic β -cell function. Recently, islet-derived cytokine PANcreatic DERived factor (PANDER or FAM3B) has also been demonstrated to be a regulator of islet β -cell function. The change in cytokine profile in islet and plasma is associated with pancreatic β -cell dysfunction and apoptosis. In this paper, we summarize and discuss the recent studies on the effects of certain important cytokines on pancreatic β -cell function. The imbalance in deleterious and protective cytokines plays pivotal roles in the development and progression of pancreatic β -cell dysfunction under insulin-resistant conditions.