Macrophage-Derived Biomarkers of Idiopathic Pulmonary Fibrosis. (29th November 2010)

• Record Type: Journal Article
• Authors: Bargagli, E.; Prasse, A.; Olivieri, C.; Muller-Quernheim, J.; Rottoli, P.
• Other Names: Halayko Andrew J. Academic Editor.
• Is Part Of: Pulmonary medicine. Volume 2011(2011)
• Publication Date: 2010-11-29
• Subjects: Lungs -- Diseases -- Periodicals; Lung Diseases; Lungs -- Diseases; Electronic journals; Periodicals; Electronic journals -- Sciences; Electronic journals -- Medicine; Periodicals; 616.24
• DOI: 10.1155/2011/717130
• Languages: English
• ISSNs: 2090-1836

Abstract

Abstract : Idiopathic pulmonary fibrosis (IPF) is a severe, rapidly progressive diffuse lung disease. Several pathogenetic mechanisms have been hypothesized on the basis of the fibrotic lung damage occurring in this disease, and a potential profibrotic role of activated alveolar macrophages and their mediators in the pathogenesis of IPF was recently documented. This paper focuses on recent literature on potential biomarkers of IPF derived from activated alveolar macrophages. Biomarker discovery and clinical application are a recent topic of interest in the field of interstitial lung diseases (ILDs). Cytokines, CC-chemokines, and other macrophage-produced mediators are the most promising prognostic biomarkers. Many molecules have been proposed in the literature as potential biomarker of IPF; however, a rigorous validation is needed to confirm their clinical utility.