Bone Mineral Density in Thalassemia Major Patients from Antalya, Turkey. (7th May 2012)

• Record Type: Journal Article
• Authors: Aslan, Ibrahim; Canatan, Duran; Balta, Nihal; Kacar, Gulizar; Dorak, Cengaver; Ozsancak, Ahmet; Oguz, Nurgul; Cosan, Ruya
• Other Names: Dufau Maria L. Academic Editor.
• Is Part Of: International journal of endocrinology. Volume 2012(2012)
• Publication Date: 2012-05-07
• Subjects: Endocrinology -- Periodicals; Endocrinology; Endocrinology -- Periodicals; Endocrine System Diseases -- Periodicals; Periodicals; 616.4
• DOI: 10.1155/2012/573298
• Languages: English
• ISSNs: 1687-8337

Abstract

Abstract : Aim . We assessed the bone mineral density and related parameters in nine adults, thirty-eight pubertal, prepubertal totally forty-seven patients with thalassemia major living in Antalya, Turkey. Materials and Methods . We measured height and pubertal staging in last five years by six-month intervals. Average ferritin and hemoglobin concentrations were calculated for last three years. The levels of hydroxyproline, calcium, phosphorus, and creatinine were measured in 24 h urine, and those of parathormone, IGF 1, osteocalcine, alkaline phosphatase, calcium, ionized calcium, magnesium, phosphorus, creatine, blood glucose, thyroid stimulating hormone, alanine transaminase, and aspartate transaminase were determined in serum, and also the bone mineral density was measured. Results . The average L1–L4 bone mass density was27.1 ± 10.1 g cm −2 ; the average bone mineral content was0.65 ± 0.11 g. of the patients with a Z-score under 2.5. A moderate relationship was found between the bone mass density age and height. Subjects in low pubertal staging and short stature (<3% percentile) have significantly lower bone mass densitiesP < 0.001 . Conclusion . he prevalence of osteoporosis is high in patients with thalassemia major, possibly related to delayed puberty.