Association of HLA-B∗38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients. (5th July 2018)

• Record Type: Journal Article
• Authors: Thao, Mai Phuong; Tuan, Pham Vo Anh; Linh, Le Gia Hoang; Van Hoang, Lam; Hen, Phan Huu; Hoa, Le Tuyet; Vu, Hoang Anh; Minh, Do Duc
• Other Names: Magri Flavia Academic Editor.
• Is Part Of: International journal of endocrinology. Volume 2018(2018)
• Publication Date: 2018-07-05
• Subjects: Endocrinology -- Periodicals; Endocrinology; Endocrinology -- Periodicals; Endocrine System Diseases -- Periodicals; Periodicals; 616.4
• DOI: 10.1155/2018/7965346
• Languages: English
• ISSNs: 1687-8337

Abstract

Abstract : Background . HLA-B ∗ 38:02 has been shown to be associated with antithyroid drug-induced agranulocytosis in Asian patients. Methods . HLA-B ∗ 38:02 was analyzed by sequence-based typing in 21 patients who developed antithyroid drug-induced agranulocytosis and in 81 controls. Results . Frequency of HLA-B ∗ 38:02 was 52.4% in agranulocytosis patients compared to 3.7% in controls (OR = 28.6, 95% CI = 6.8–120.2). Conclusions . HLA-B ∗ 38:02 is a significant risk factor for agranulocytosis in Kinh Vietnamese patients treated with antithyroid drug.