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Pre‐Metastatic Niches: Macrophages‐Triggered Sequential Remodeling of Endothelium‐Interstitial Matrix to Form Pre‐Metastatic Niche in Microfluidic Tumor Microenvironment (Adv. Sci. 11/2019). Issue 11 (4th June 2019)
Record Type:
Journal Article
Title:
Pre‐Metastatic Niches: Macrophages‐Triggered Sequential Remodeling of Endothelium‐Interstitial Matrix to Form Pre‐Metastatic Niche in Microfluidic Tumor Microenvironment (Adv. Sci. 11/2019). Issue 11 (4th June 2019)
Main Title:
Pre‐Metastatic Niches: Macrophages‐Triggered Sequential Remodeling of Endothelium‐Interstitial Matrix to Form Pre‐Metastatic Niche in Microfluidic Tumor Microenvironment (Adv. Sci. 11/2019)
Abstract : In article number1900195, Seok Chung, Seung Hyeok Seok, and co‐workers take the first step in providing direct evidence of sequential establishment of the pre‐metastatic niche triggered by monocytes and macrophages. The monocytes/macrophages‐mediated remodeling of endothelium‐interstitial matrix leads down a slippery slope for the circulating cancer cells to invade toward metastasis.