Epimagnolin A inhibits IL‐6 production by inhibiting p38/NF‐κB and AP‐1 signaling pathways in PMA‐stimulated THP‐1 cells. Issue 7 (27th March 2019)

• Record Type: Journal Article
• Authors: Chun, Hyun‐Woo; Kim, Soo‐Jin; Pham, Thu‐Huyen; Bak, Yesol; Oh, Jaewook; Ryu, Hyung‐Won; Oh, Sei‐Ryang; Hong, Jin‐Tae; Yoon, Do‐Young
• Is Part Of: Environmental toxicology. Volume 34:Issue 7(2019)
• Page Start: 796
• Page End: 803
• Publication Date: 2019-03-27
• Subjects: activator protein‐1 -- anti‐inflammatory -- Epimagnolin A -- NF‐κB -- p38 MPAK -- THP‐1 cells; Water quality bioassay -- Periodicals; Water -- Pollution -- Toxicology -- Periodicals; Microbiological assay -- Periodicals; Toxicity testing -- Periodicals; Environmental toxicology -- Periodicals; Environmental Pollution -- Periodicals; Environmental Pollutants -- Periodicals; Environmental Monitoring -- Periodicals; Écotoxicologie -- Périodiques; Pollution -- Périodiques; 615.902
• DOI: 10.1002/tox.22746
• Languages: English
• ISSNs: 1520-4081

Abstract

Abstract: Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal congestion. A herbal compound fargesin obtained from M. fargesii, has exerted anti‐inflammatory effects in human monocytic THP‐1 cells in the previous study. The anti‐inflammatory effects of epimagnolin A, however, have been not elucidated yet. In this study, it was demonstrated that epimagnolin A reduced phorbol‐12‐myristate‐13‐acetate (PMA)‐induced IL‐6 promoter activity and IL‐6 production in human monocytic THP‐1 cells. Furthermore, it was investigated the modulating effects of epimagnolin A on mitogen‐activated protein kinase, nuclear factor‐kappa B (NF‐κB), and activator protein 1 (AP‐1) activities. Phosphorylation of p38 and nuclear translocation of p50 and c‐Jun were down‐regulated by epimagnolin A in the PMA‐stimulated THP‐1 cell. The results revealed that epimagnolin A attenuated the binding affinity of NF‐κB and AP‐1 transcription factors to IL‐6 promoter and IL‐6 production through p38/NF‐kB and AP‐1 signaling pathways in the PMA‐stimulated THP‐1 cells. These results suggest that epimagnolin A can be a useful drug for the treatment of inflammatory diseases.