Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells. (4th July 2019)

• Record Type: Journal Article
• Authors: Beug, Shawn T.; Korneluk, Robert G.; LaCasse, Eric C.
• Is Part Of: Molecular & cellular oncology. Volume 6:Number 4(2019)
• Publication Date: 2019-07-04
• Subjects: cIAP1 -- cIAP2 -- inhibitor of apoptosis -- IAP antagonist -- SP3 -- Specificity Protein 3 -- Smac mimetic -- RIPK1 -- RNAi -- cancer -- inflammation -- MDA-MB-231; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2019.1607456
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells. In concert with Nuclear Factor kappa B (NF-κB, ) SP3 is required for the expression of the cytokine Tumor Necrosis Factor alpha (TNF-α) under basal and Smac mimetic-stimulated conditions.