Unraveling the cellular heterogeneity of malignant pleural mesothelioma through a deconvolution approach. (4th July 2019)

• Record Type: Journal Article
• Authors: Blum, Yuna; Jaurand, Marie-Claude; De Reyniès, Aurélien; Jean, Didier
• Is Part Of: Molecular & cellular oncology. Volume 6:Number 4(2019)
• Publication Date: 2019-07-04
• Subjects: Mesothelioma -- tumor heterogeneity -- deconvolution method -- molecular component -- molecular classification; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2019.1610322
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: We determined the proportions of epithelioid-like and sarcomatoid-like cellular entities within malignant pleural mesothelioma samples, by deconvolution of their transcriptomes. These proportions are associated with prognosis and may guide therapeutic strategies. This novel approach describes both intra- and inter-tumor heterogeneity and provides a new way of thinking about cancer pathology.