FBXW2 suppresses proliferation and invasion of lung cancer cells by targeting SKP2 and β-catenin. (4th July 2019)

• Record Type: Journal Article
• Authors: Yang, Fei; Sun, Yi
• Is Part Of: Molecular & cellular oncology. Volume 6:Number 4(2019)
• Publication Date: 2019-07-04
• Subjects: Lung cancer -- FBXW2 -- SKP2 -- β-catenin -- proliferation and invasion -- ubiquitylation and degradation; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2019.1607458
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: F-box protein is a substrate-receptor of SKP1-Cullin1-F-box protein (SCF) E3 ligase, but the function of many family members remains elusive. We found that F-box and WD-repeat domain-containing 2 (FBXW2) inhibits proliferation and invasion of lung cancer cells by targeting S phase kinase-associated protein 2 (SKP2) and β-catenin for degradation. Lower FBXW2 predicts a worse patient survival. Thus, FBXW2 appears a lung tumor suppressor.