Genome instability triggered by the V(D)J recombination by-product. (4th July 2019)

• Record Type: Journal Article
• Authors: Kirkham, Christopher M.; Boyes, Joan
• Is Part Of: Molecular & cellular oncology. Volume 6:Number 4(2019)
• Publication Date: 2019-07-04
• Subjects: V(D)J recombination -- double strand breaks -- chromosome translocations -- RAG recombinase -- genome instability -- acute lymphoblastic leukemia; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2019.1610323
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: A newly identified process by which mistargeted V(D)J recombination could cause genome instability in childhood leukemia has been discovered. In this mechanism, called cut-and-run, the excised DNA by-products of V(D)J recombination are re-bound by the recombinase proteins and erroneously trigger double-strand breaks at multiple locations throughout the genome. Many of these breakpoints co-localize with known chromosome alterations in acute lymphoblastic leukemia (ALL).