A new labdane-type diterpenoid from Leonurus japonicus. Issue 7 (3rd July 2019)

• Record Type: Journal Article
• Authors: Jiang, Min-Hong; Hu, Yue; Jiao, Lin; Dong, Pan; Yin, Sheng; Zhao, Zhi-Min; Yang, De-Po; Wang, Dong-Mei
• Is Part Of: Journal of Asian natural products research. Volume 21:Issue 7(2019)
• Page Start: 627
• Page End: 632
• Publication Date: 2019-07-03
• Subjects: Labiatae -- Leonurus japonicus -- labdane-type diterpenoids -- cytotoxic activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1463997
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Five fractions prepared from the crude extract of Leonurus japonicus were examined in order to determine their cytotoxic potential. Under the bioassay guidance, a new labdane-type diterpenoid (1 ), and nine known ones (2–10 ) along with a seco -labdane (11 ) were isolated from the aerial parts of Leonurus japonicus . The structure elucidation was primarily based on comprehensive spectroscopic analyses, including HRESIMS, IR, and 1D and 2D NMR methods. Compound4 (6β-hydroxy-15, 16-epoxylabda-8, 13(16), 14-trien-7-one) exhibited potential cytotoxicity against HeLa cell line (IC50 = 23.75 μM). Abstract :