Report of in vitro antileishmanial properties of Iberian macroalgae. Issue 12 (18th June 2019)

• Record Type: Journal Article
• Authors: Bruno de Sousa, Carolina; Lago, João Henrique G.; Macridachis, Jorge; Oliveira, Marta; Brito, Luis; Vizetto-Duarte, Catarina; Florindo, Cláudia; Hendrickx, Sarah; Maes, Louis; Morais, Thiago; Uemi, Miriam; Neto, Luís; Dionísio, Lídia; Cortes, Sofia; Barreira, Luísa; Custódio, Luísa; Alberício, Fernando; Campino, Lenea; Varela, João
• Is Part Of: Natural product research. Volume 33:Issue 12(2019)
• Page Start: 1778
• Page End: 1782
• Publication Date: 2019-06-18
• Subjects: Antiparasitic -- Leishmania infantum -- leishmaniasis -- macroalgae -- Cystoseira -- secondary metabolites; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1434637
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Here is reported the anti Leishmania infantum activity of 48 hexane, CH2 Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2 Cl2 Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8–101.8 μg/mL) inducing strong morphological alterations in the parasites. Hexane extracts of C. baccata and C. barbata were also active against intracellular amastigotes (IC50 5.1 and 6.8 μg/mL, respectively). Fatty acids, triacylglycerols, carotenoids, steroids and meroterpenoids were detected by nuclear magnetic resonance (NMR), and gas chromatography in the Cystoseira extracts. These results suggest that Cystoseira macroalgae contain compounds with antileishmanial activity, which could be explored as scaffolds to the development of novel sources of antiparasitic derivatives. Abstract :