Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis. (4th July 2019)
- Record Type:
- Journal Article
- Title:
- Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis. (4th July 2019)
- Main Title:
- Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis
- Authors:
- Beauvarlet, Jennifer
Mergny, Jean-Louis
Djavaheri-Mergny, Mojgan - Abstract:
- ABSTRACT: G-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ligand20A promotes senescence in cancer cells through Ataxia Telangiectasia Mutated (ATM) and autophagy activation. Inhibition of both pathways directs cells to apoptosis, positioning ATM/autophagy axis as a linchpin between senescence and apoptosis.
- Is Part Of:
- Molecular & cellular oncology. Volume 6:Number 4(2019)
- Journal:
- Molecular & cellular oncology
- Issue:
- Volume 6:Number 4(2019)
- Issue Display:
- Volume 6, Issue 4 (2019)
- Year:
- 2019
- Volume:
- 6
- Issue:
- 4
- Issue Sort Value:
- 2019-0006-0004-0000
- Page Start:
- Page End:
- Publication Date:
- 2019-07-04
- Subjects:
- Cancer therapy -- G-quadruplex -- autophagy -- DNA damage response -- senescence
Tumors -- Periodicals
Neoplasms
Periodicals
616.99 - Journal URLs:
- http://www.tandfonline.com/loi/kmco20#.VyIIeFL2aic ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/23723556.2019.1604047 ↗
- Languages:
- English
- ISSNs:
- 2372-3556
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 10687.xml